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Researchers have found the “bad seeds” of liver cancer and believe they could one day reprogram them to remain responsive to cancer treatment, a new study has found.
The key to disrupting chemo-resistant stem cells that become liver tumors from multiplying is to target the stem cell marker NANOG, said Keigo Machida, senior author and associate professor of molecular microbiology and immunology at the Keck School of Medicine of USC.
NANOG is scarce in early-stage cancer but abounds in Stage III liver cancer. It promotes the cancer’s spread by rewiring metabolism in the mitochondria — a cell’s energy factory.
“We identified the Achilles heel in cancer therapy,” Machida said. “There are bad seeds in cancer. Even though we treat patients with chemotherapy, those bad seeds survive and force relapse. That’s why we would like to target the bad seeds in cancer to eradicate recurrence problems and metastasis, which is when the cancer spreads to other parts of the body.”
The study will be published in the Jan. 12 issue of the
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Stroke is a condition wherein the flow of blood to the brain is disrupted due to a blood clot or ruptured blood vessel or artery. A lack of oxygen or glucose in the blood causes brain damage or death of the brain cells. This leads to speechlessness or loss of memory or impairment of any part of the body.
Types and severity of stroke
There are two major types of strokes namely ischemic and hemorrhagic. The former is the more prevalent as it is observed in close to 75% of the stroke patients. This type of stroke happens when there is a blood clot or thrombus that disrupts the flow of blood to the brain. The clotting of blood in any part of the body causing free-floating of the blood is termed as embolus. This type of circulating blood clot if carried to the brain causes ischemic stroke. The hemorrhagic stroke generally occurs when the blood in any part of the brain fills the space between the brain and the skull. This condition may be caused when any of the blood vessel or artery in the brain ruptures
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